Study of the pathogenesis and reversibility of airway damage and repair (remodeling) during chronic mucosal immune response to environmental allergens in a large animal model of asthma.

研究大型哮喘动物模型对环境过敏原的慢性粘膜免疫反应过程中气道损伤和修复（重塑）的发病机制和可逆性。

• 批准号: 188748
• 负责人: Lavoie Jean-Pierre
• 金额: $ 46.39万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=188748&lang=en
• 关键词: Airway Smooth Muscle Remodeling; Equine Heaves; Expression Arrays (Ssh; Extracellular Matrix; Laser Microdissection; Lung Function; Microarrays)

In human asthma, repeated exposure to environmental allergens leads to persistent inflammation and damage (remodeling) of the lungs, and a progressive loss of airway function. Our proposed studies aim to determine 1) if the lesions present in the lung tis

在人类哮喘中，反复暴露于环境过敏原会导致持续性炎症和损害(重塑)。 肺部受损，以及呼吸道功能的进行性丧失。我们建议的研究目的是确定1)如果病变出现在 肺炎