Investigating the Role of Lymphocyte Activating Gene-3 (LAG-3) in HIV Susceptibility

研究淋巴细胞激活基因 3 (LAG-3) 在 HIV 易感性中的作用

• 批准号: 449542
• 负责人: Mohideen Shifa F
• 金额: $ 1.27万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449542&lang=en
• 关键词: Anti-Lag-3 Antibody Blockade; Cd223; Hiv Immunotherapy; Hiv Receptors; Hiv Susceptibility; Immune Checkpoint Molecules; Inhibitory Receptors; Lymphocyte Activation Gene-3; T-Cell Exhaustion And Dysfunction; Viral Entry

Over 38 million people are still infected with HIV (Human Immunodeficiency Virus) to this day, despite the use of antiretroviral therapy to combat HIV infection. Like a lock and key, the virus uses CD4 on human T-cells to attach and enter cells, for infec

尽管使用抗逆转录病毒疗法来对抗 HIV 感染，但迄今为止仍有超过 3800 万人感染 HIV（人类免疫缺陷病毒）。就像锁和钥匙一样，该病毒利用人类 T 细胞上的 CD4 来附着和进入细胞，以进行感染