Problems in Bioinorganic and Metal Cluster Chemistry

该奖项在无机，生物无机和有机 化学计划将支持教授继续研究 R. H.哈佛大学的霍尔姆在几个领域， 生物无机化学 需要调查的领域包括：1） 钼氧代转移酶，包括类似物的合成， 兔肝醛氧化酶的同位素标记研究 固氮酶辅因子模型的合成; 3） 镍酶氢化酶和CO的功能模型 脱氢酶。 在所有的模拟研究中， 提供酶的功能模拟物的合成模型 行动上 在生物学相关性较低的领域调查 由可溶性氯化物合成分子簇 硫代硫酸盐和通过从不溶性， 非分子固体将被采用。 %%% 许多酶的性质是精确的分子 结构和机械细节不能由 传统的物理技术。 各种间接 方法已经发展，可以用来推断酶 并帮助定义各个化学步骤 参与其催化机制。 的应用和 开发这些间接方法的目的是 research.

This award in the Inorganic, Bioinorganic and Organometallic Chemistry Program will support continued studies by Professor R. H. Holm of Harvard University in several areas of bioinorganic chemistry. Areas to be investigated include 1) molybdenum oxotransferases including synthesis of analogues and isotopic labeling studies of rabbit liver aldehyde oxidase; 2) synthesis of models for the cofactors of nitrogenase; 3) functional models of the nickel enzymes hydrogenase and CO dehydrogenase. In all analogue studies emphasis is on synthetic models that provide functional mimics of the enzyme action. In a less biologically related area investigations of the synthesis of molecular chalogenide clusters from soluble thiometallates and by excision of fragments from insoluble, nonmolecular solids will be undertaken. %%% The nature of many enzymes is such that precise molecular structures and mechanistic details cannot be determined by conventional physical techniques. A variety of indirect methods have evolved that can be used to infer enzyme structures and to help define the individual chemical steps involved in their catalytic mechanisms. The application and development of these indirect methods is the purpose of this research.