Local protein synthesis at presynaptic terminals in learning and memory

学习和记忆中突触前末梢的局部蛋白质合成

• 批准号: 441239
• 负责人: Wong Hovy Ho Wai
• 金额: $ 9.83万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441239&lang=en
• 关键词: 2-Photon Microscopy; Axonal Translation; Electrophysiology; Learning And Memory; Local Protein Synthesis; Neurotransmission; Nmda Receptors; Photo-Uncaging; Quadruple Whole-Cell Recordings; Synaptic Plasitcity

Long-term memory formation requires synthesis of new proteins, which are the basic biological building blocks and function executors. Perplexingly, the tiny connections between brain cells, known as synapses, are often located far away from the cell body

长期记忆的形成需要合成新的蛋白质，这是基本的生物构建块和功能执行者。令人费解的是，脑细胞之间被称为突触的微小连接通常位于远离细胞体的地方