Catalytic Activation and Oxidation of C-H Bonds by Soluble Platinum Compounds

这一奖项在无机、生物无机和有机金属项目中继续支持宾夕法尼亚州立大学化学系的Ayusman Sen博士关于碳氢键氧化的研究。SEN发现，未激活的C-H键会被铂(II)络合物选择性地攻击，而铂(0)会激活C-H键与氧或氮的结合。他建议研究体系的机理细节，以表征C-H活化步骤、中间有机金属物种的结构和反应活性、可使体系催化的辅氧化剂类型以及选择性的来源。在温和的条件下，铂(II)可以在水溶液中氧化多种有机化合物，如烷烃、醚和醇。这种对有机合成可能非常有用的反应还没有被很好地理解。森将对反应如何进行进行详细调查，以发现如何使其与包含许多碳氢键的系统中的特定碳氢键反应。研究结果对化工制造行业的规模化生产和特种产品的生产都具有一定的实用价值。

This award in the Inorganic, Bioinorganic, and Organometallic Program provides continued support for research by Dr. Ayusman Sen of the Chemistry Department, Pennsylvania State University, concerning the oxidation of carbon-hydrogen bonds. Sen has found that unactivated C-H bonds are attacked selectively by Pt(II) complexes, whereas Pt(0) activates C-H bonds alpha to oxygen or nitrogen. He proposes to study the mechanistic details of the system in order to characterize the C-H activation step, the structure and reactivity of the intermediate organometallic species, the types of cooxidants that could make the system catalytic, and the origins of the selectivity. %%% A variety of organic compounds, such as alkanes, ethers, and alcohols, can be oxidized in aqueous solution under mild conditions by platinum (II). This potentially very useful reaction for organic synthesis is not well understood. Sen will carry out a detailed investigation of how the reaction proceeds in order to discover how it can be made to react with specific carbon-hydrogen bonds in a system that contains many carbon-hydrogen bonds. The results have utility in the chemical manufacturing industry, both for the production of large scale and specialty products.