Environmental Control of Photochemical Reactions and Its Application

将研究反应性发色团附着在两亲分子疏水尾部的光化学和光物理后果。该计划的主旨将是确定微非均相系统的结构特征，这些结构特征决定了所产生的反应过程。待研究的反应基团包括苯乙烯基和苯乙烯基。将利用双功能磷脂来提供具有空间精确几何形状的分子种类。这些几何结构将反应性官能团置于有利的位置，如环加成反应。反应基团之间的相互作用，如二苯乙烯，苯乙烯和多烯将在稀释，混合和纯分散研究，试图分离分子间和分子内的过程。这项来自有机动力学项目的资助用于支持罗切斯特大学David Whitten教授的持续工作。这些研究将旨在更好地了解控制非均相系统中化学反应的因素。要研究的系统是具有亲水性（被水吸引）和疏水性（被水排斥）特性的独特分子。通过将对光有反应的化学基团作为这些分子的组成部分，有可能产生各种各样的反应，否则这些反应可能不会发生。对医学和材料科学领域的影响是无数的。

The photochemical and photophysical consequences of attaching reactive chromophores to the hydrohpobic tail of amphiphilic molecules will be investigated. The thrust of the program will be to define the structural features of the microheterogeneous systems which dictate the resultant reaction processes. The reactive groups to be investigated include styryl and stilbene moieties. Bifunctional phospholipids will be utilized in order to provide molecular species which have spatially exact geometries. These geometries place reactive functional groups in favorable positions for reactions such as cycloadditions. Interactions between reactive groups such as stilbenes, styrenes, and polyenes will be studied in dilute, mixed, and pure dispersions in an attempt to separate intermolecular and intramolecular processes. %%% This grant from the Organic Dynamics Program supports the continuing work of Professor David Whitten at the University of Rochester. The studies will be directed to establishing a better understanding of the factors which control chemical reactions in heterogeneous systems. The systems to be investigated are unique molecules which have both hydrophilic (attracted to water) and hydrophobic (repelled by water) properties. By incorporating reactive chemical groups that are responsive to light as an integral part of these molecules, it is possible to produce a variety of reactions which might otherwise fail to occur. Implications for the medical and materials areas of science are numerous.