Environmental Control of Photochemical Reactions and Its Application

我们将研究将活性发色团附着到两亲性分子的亲水尾巴上的光化学和光物理后果。该计划的主旨将是确定微多相系统的结构特征，这些结构特征决定了所产生的反应过程。要研究的活性基团包括苯乙烯基和二苯乙烯基团。双功能磷脂将被用来提供具有精确空间几何构型的分子物种。这些几何构型将反应性官能团置于反应的有利位置，如环加成反应。我们将在稀散、混合和纯分散体系中研究二苯乙烯、苯乙烯和多烯等活性基团之间的相互作用，试图将分子间和分子内过程分开。来自有机动力学项目的这笔赠款支持罗切斯特大学大卫·惠顿教授的继续工作。这些研究旨在更好地理解控制非均相体系中化学反应的因素。要研究的体系是既具有亲水性(被水吸引)又具有疏水性(被水排斥)的独特分子。通过将对光反应的活性化学基团作为这些分子的组成部分，就有可能产生各种各样的反应，否则这些反应可能无法发生。对医学和材料科学领域的影响是多方面的。

The photochemical and photophysical consequences of attaching reactive chromophores to the hydrohpobic tail of amphiphilic molecules will be investigated. The thrust of the program will be to define the structural features of the microheterogeneous systems which dictate the resultant reaction processes. The reactive groups to be investigated include styryl and stilbene moieties. Bifunctional phospholipids will be utilized in order to provide molecular species which have spatially exact geometries. These geometries place reactive functional groups in favorable positions for reactions such as cycloadditions. Interactions between reactive groups such as stilbenes, styrenes, and polyenes will be studied in dilute, mixed, and pure dispersions in an attempt to separate intermolecular and intramolecular processes. %%% This grant from the Organic Dynamics Program supports the continuing work of Professor David Whitten at the University of Rochester. The studies will be directed to establishing a better understanding of the factors which control chemical reactions in heterogeneous systems. The systems to be investigated are unique molecules which have both hydrophilic (attracted to water) and hydrophobic (repelled by water) properties. By incorporating reactive chemical groups that are responsive to light as an integral part of these molecules, it is possible to produce a variety of reactions which might otherwise fail to occur. Implications for the medical and materials areas of science are numerous.