Dissecting the molecular mechanism for prostaglandin F2 alpha receptor biased signaling

剖析前列腺素 F2 α 受体偏向信号传导的分子机制

• 批准号: 445366
• 负责人: Audet Martin
• 金额: $ 47.37万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=445366&lang=en
• 关键词: Biased Signalling; G Protein-Coupled Receptors (Gpcr); Heterotrimeric G Proteins; Molecular Modelling; Preterm Birth; Prostaglandin F2 Alpha Receptor; Signalling Effectors; Structural Biology; Virtual Ligand Screening; X-Ray Crystallography

Preterm birth, which is the leading cause of death of children under 5-year-old worldwide, involves the obligatory mediator: prostaglandin F2alpha receptor (FP), a lipid mediator receptor that controls the onset of uterus contraction. In Canada, preterm b

早产是全球5岁以下儿童死亡的主要原因，涉及强制性介质：前列腺素F2 α受体（FP），一种控制子宫收缩开始的脂质介质受体。在加拿大，早产儿B