Role of altered endoplasmic reticulum calcium regulation and the N-methyl-D-aspartate (NMDA) receptor signaling in cortico-striatal synaptic dysfunction: Opportunities for therapy in prodromal Huntington disease

改变的内质网钙调节和 N-甲基-D-天冬氨酸 (NMDA) 受体信号在皮质纹状体突触功能障碍中的作用：前驱期亨廷顿病的治疗机会

• 批准号: 443591
• 负责人: Raymond Lynn A
• 金额: $ 80.53万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=443591&lang=en
• 关键词: Cortex; Cytosol-To-Nuclear Calcium Signaling; Endoplasmic Reticulum; Genetic Mouse Models; Glutamate Release; Huntington Disease; Motor Learning; Nmda Receptor; Striatum; Synaptic Transmission

Brain diseases characterized by age-related progressive loss of neural tissue (neurodegeneration), like Alzheimer and Parkinson disease, often start with abnormal connectivity between brain cells and regions. Huntington disease (HD) is an inherited brain

以年龄相关的神经组织进行性丧失（神经变性）为特征的脑部疾病，如阿尔茨海默病和帕金森病，通常始于脑细胞和区域之间的异常连接。亨廷顿病（HD）是一种遗传性脑