Catalysis and Mechanism in Nucleophilic Aromatic Photosubstitution

亲核芳香光取代的催化及机理

• 批准号: 9216857
• 负责人: Gene Wubbels
• 金额: $ 8.7万
• 依托单位: Washington College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-15 至 1995-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9216857&HistoricalAwards=false
• 关键词: Catalysis; Mechanism; Nucleophilic; Aromatic; Photosubstitution

An investigation of catalysis of homogeneous photochemical reactions and mechanisms of nucleophilic aromatic photosubstitution reactions will be conducted. By the determination of Bronsted Catalysis Law plots, evidence for electron hole transfer catalysis involving hydroxide ion will be obtained. In addition, the structural requirements which govern instances where base catalysis competes with quenching will be defined. The identity of intermediate structures involved in intramolecular photodisplacement of hydrogen on an aromatic ring will be determined, and for the first time the "element effect" on nucleophilic aromatic photosubstitution will be elucidated. %%% This grant from the Organic Dynamics Program will suport research on photoinduced nucleophilic aromatic substitution in the laboratoty of Professor G. G. Wubbels at Washington College. The focus of the research will be to explore the nature of Bronsted Catalysis plots and thereby provide definitive evidence for electron hole catalysis involving hydroxide ion. Elucidation of the structural parameters which govern such processes will lead to the development of more efficient methods for generating substituted aromatic compounds.

研究了均相光化学反应的催化作用和亲核芳族光取代反应的机理。通过测定Bronsted催化定律图，获得了涉及氢氧离子的电子空穴转移催化的证据。此外，还将定义控制碱催化与淬火竞争的结构要求。确定了参与芳环上氢分子内光置换的中间结构，并首次阐明了亲核芳环光置换的“元素效应”。这项来自有机动力学项目的资助将支持华盛顿学院G. G. Wubbels教授实验室光诱导亲核芳香族取代的研究。研究的重点将是探索Bronsted催化图的性质，从而为涉及氢氧根离子的电子空穴催化提供明确的证据。阐明控制这些过程的结构参数将导致开发更有效的方法来生成取代芳香族化合物。