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Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders

Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders
视网膜反应改变是主要精神疾病风险轨迹和发育病理生理学的神经生物学组成部分
批准号：
451313
负责人：
Maziade Michel G
金额：
$80.53万
依托单位：
Centre hospitalier Robert-Giffard (Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=451313&lang=en
关键词：
Bipolar Disorder Child Mental Healt Childhood Trauma Electroretinogram Major Depression Neurodevelopment Retina Risk Studies Schizophrenia Youth At Risk

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中文摘要
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英文摘要
A neurodevelopmental origin is likely in schizophrenia, bipolar disorder and recurrent major depression. The pathophysiology remains mysterious mainly due to difficulties in accessing living neuronal tissue in high-risk youths. The study of the retina, by
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Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population
  • 批准号：
    434047
  • 项目类别：
    Operating Grants
  • 资助金额：
    $83.32万
  • 财政年份：
    2020
  • 负责人：
    Maziade Michel G
  • 依托单位：
    CERVO Brain Research Center (Qubec)
Intercepting the "childhood risk syndrome" of schizophrenia and mood disorders along the developmental trajectory: A preclinical staging of children and adolescents at genetic risk
Developmental course of cognitive and electroretinographic precursors from childhood to adulthood in children and adolescents at risk of schizophrenia and bipolar disorder
Genomic follow-up of the susceptibility loci for SZ and BP in multi-affected families of Eastern Quebec