Elucidating the role of TCOF1 in the nucleolar response to ribosomal DNA damage

阐明 TCOF1 在核糖体 DNA 损伤的核仁反应中的作用

• 批准号: 458662
• 负责人: Panichnantakul Pudchalaluck
• 金额: $ 7.65万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458662&lang=en
• 关键词: Genetic Crispr-Cas9 Screen; Nucleolar Caps, Immunofluorescence; Nucleolar Dna Damage Response; Proteomics - Affinity Purification, Bioid; Ribosomal Dna And Genome Instability

The preservation of genetic material is essential for cell proliferation and survival. Unstable or damaged DNA can result in mutations and subsequently contribute to diseases which include a multitude of human cancers. The nucleolus is a sub-compartment o

遗传物质的保存对细胞增殖和存活至关重要。不稳定或受损的DNA可能导致突变，随后导致包括多种人类癌症在内的疾病。核仁是细胞的一个亚区室，