US-Poland Joint Fund Research on Mechanisms Controlling Intramuscular Lipid Metabolism

美国-波兰联合基金控制肌内脂质代谢机制研究

• 批准号: 9223864
• 负责人: Hanna Kaciuba-Uscilko
• 金额: --
• 依托单位: Polish Academy of Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1996-01-01
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9223864&HistoricalAwards=false
• 关键词: US; Poland; Joint; Fund; Research

This US-Poland Marie Sklodowska-Curie Joint Fund research project between Dr. Hanna Kaciuba-Uscilko of the Department of Applied Physiology, Medical Research Center, Polish Academy of Sciences, Warsaw, and Dr. Ronald L. Terjung, Department of Physiology, State University of New York, Syracuse, is on "Mechanisms Controlling Intramuscular Lipid Metabolism." Skeletal muscles play an important role in the whole lipid metabolism since they remove a considerable amount of circulating lipids that are partly oxidized and partly stored, forming an intramuscular triacylglycerol (TG) pool. However, contribution of intramuscular TG to energy metabolism at rest and during exercise as well as systemic and local mechanisms controlling TG synthesis and utilization in muscle cells are poorly recognized. The purposes of the planned study are: (1) to elaborate an adequate system for quantitative estimation of intramuscular TG metabolic turnover; (2) to determine an influence of muscle contractions of different intensity and duration on the rate of synthesis and utilization of intramuscular TG, and to estimate TG contribution to exercise energy metabolism; (3) to investigate the effects of physical training, nutritional status, dietary modifications and some hormones on the intramuscular TG metabolism; (4) to evaluate interactions between the systems controlling intramuscular TG metabolism, the mechanisms of lipid removal from the plasma by skeletal muscles and the whole body lipid metabolism. The results are supposed to enlarge the understanding of metabolic adaptation to physical work, and dietary modifications and the role of physiological factors in prevention and therapy of some lipid metabolism disturbances-- e.g., atherosclerosis, obesity. This project in physiology fulfills the program objective of advancing scientific knowledge by enabling leading experts in Poland and the United States to combine complementary talents and pool resources in areas of strong mutual interest and competence.

这个美国-波兰玛丽斯克洛多夫斯卡-居里联合 资助汉娜博士 Kaciuba-Uscilko，应用教育部 生理学，医学研究中心，波兰 华沙科学院和罗纳德L. Terjung，生理学系，国家 位于锡拉丘兹的纽约大学 “控制肌内脂质的机制 新陈代谢.“skeleton muscle play an 在整个脂质代谢中的重要作用 因为它们去除了大量 部分氧化的循环脂质， 部分储存，形成肌内 三酰甘油（TG）池。 然而，在这方面， 肌内甘油三酯对能量的贡献 休息时和运动时的新陈代谢 作为控制TG的系统和局部机制 在肌肉细胞中合成和利用， 不好认。 计划的目的 研究内容是：（1）建立一个适当的制度 用于定量估计肌内TG 代谢周转;（2）确定 不同肌肉收缩的影响 强度和持续时间对合成速率的影响 和肌内TG的利用， 估计TG对运动能量的贡献 代谢;（3）研究 体育锻炼，营养状况，饮食 修改和一些激素对 肌内TG代谢;（4）评估 控制系统之间的相互作用 肌内TG代谢， 通过骨骼肌从血浆中清除脂质 肌肉和全身脂质代谢。 结果应该是扩大了 了解代谢适应 体力劳动，饮食调整， 生理因素在预防中的作用 以及某些脂质代谢的治疗 干扰--例如，动脉粥样硬化肥胖症 这个生理学的项目实现了 科学知识的目标， 使波兰的顶尖专家和 美国将联合收割机互补人才 并将资源集中在相互关系密切的领域， 兴趣和能力。