Identification of the mechanisms underlying the early stages of leukemogenesis in human hematopoietic stem cells.

鉴定人类造血干细胞白血病发生早期的机制。

• 批准号: 463108
• 负责人: Eppert Kolja
• 金额: $ 65.48万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=463108&lang=en
• 关键词: Acute Myeloid Leukemia; Hematopoiesis; Hematopoietic Stem Cell; Pre-Leukemia; Stem Cell Biology

The goal of this project is to study how normal blood cells transition to an abnormal pre-cancerous cell that then progresses to a full cancer. Individuals can be otherwise healthy but carry mutations in blood cell stem cells that put them at risk for dev

该项目的目标是研究正常血细胞如何转变为异常癌前细胞，然后发展为完全癌症。个体可以在其他方面健康，但携带血细胞干细胞突变，使他们处于发展的风险之中。