Investigating the metabolic drivers of hyperinflammation during viral infection

研究病毒感染期间过度炎症的代谢驱动因素

• 批准号: 462594
• 负责人: Ashkar Ali A
• 金额: $ 76.07万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462594&lang=en
• 关键词: Hyperinflamation; Immunometabolisem; Innate Antiviral Immunity; Mucosal Viral Infections

Successful host defense requires tight control of inflammation to mount an effective immune response while limiting damage to the host. Loss of such inflammatory control can result in "cytokine storm" - a pathological dysregulated immune response characte

成功的宿主防御需要严格控制炎症，以产生有效的免疫反应，同时限制对宿主的损害。这种炎症控制的丧失可导致“细胞因子风暴”--一种病理性失调的免疫反应特征，