Programmed Glycosylation Changes in Controlling the Germinal Center

控制生发中心的程序化糖基化变化

• 批准号: 462807
• 负责人: Macauley Matthew S
• 金额: $ 62.7万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462807&lang=en
• 关键词: Antibody; Antibody Affinity Maturation; B Cell; Carbohydrate; Cell-Cell Interactions; Germinal Centre,; Glycan; Humoral Immunity,; Somatic Hypermutation; T Cell

Cell surface carbohydrates, referred to as glycans, cover all cells and play many important physiological roles. On immune cells, immunomodulatory glycan-binding proteins (GBPs) integrate signals from the outside of the cell to changes inside. Glycans can

细胞表面碳水化合物，称为聚糖，覆盖所有细胞并发挥许多重要的生理作用。在免疫细胞上，免疫调节性聚糖结合蛋白（GBP）将来自细胞外部的信号整合到细胞内部的变化中。聚糖可