Organic Chemistry: Multistep Synthesis, New Synthetic Methodology, Exploratory Chemistry, Bioorganic Chemistry

有机化学：多步合成、新合成方法、探索化学、生物有机化学

• 批准号: 9300276
• 负责人: Elias Corey
• 金额: $ 205.5万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-15 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9300276&HistoricalAwards=false
• 关键词: Organic; Chemistry; Multistep; Synthesis; New

This work will focus on the total synthesis of a diverse group of important natural products and on the development of new synthetic methodology. Synthetic targets include: oleanolic acid, miroestrol, paeoniflorin, prostaglandin H2, lactacystin, ovalicin, cassioside, epibatidine and brefeldin A. The methodology topics chosen include: enantioselective addition of vinyl and alkynyl groups to aldehydes and ketones, enantioselective reduction of ketones, syntheses of chiral oxiranes, catalytic syntheses of new chiral controller groups, exploratory chemistry of chiral oxazaaluminolidines and chiral cationc oxazaborolidines, exploratory research on new titanium (IV) complexes as enantioselective catalysts, use of amino-acid derived catalysts for enantioselective synthesis and new methodology for the preparation of medium- and large-ring terpenoids. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Elias J. Corey of the Department of Chemistry at Harvard University. Professor Corey will focus his work on the synthesis of several naturally occurring and biologically active complex organic molecules. He will also pursue the development of new synthetic methodology

这项工作将侧重于各种重要天然产物的全合成和开发新的合成方法。合成目标包括：齐墩果酸、米洛雌酚、芍药苷、前列腺素H2、乳糖菌素、卵黄素、决明子苷、表巴替丁和灯盏花素A。选择的方法学主题包括：醛和酮的乙烯基和炔基的不对称加成，酮的不对称还原，手性环氧杂环的合成，新手性控制基团的催化合成，手性恶杂铝化合物和手性阳离子恶唑硼烷的探索化学，新型钛(IV)配合物作为对映选择性催化剂的探索性研究，氨基酸衍生催化剂在对映选择性合成中的应用，以及制备中环和大环萜类化合物的新方法。%有了这个续约奖，合成有机计划正在支持哈佛大学化学系的Elias J.Corey博士的研究。科里教授将把他的工作重点放在合成几种天然存在的具有生物活性的复杂有机分子上。他还将致力于开发新的合成方法论