Organic Chemistry: Multistep Synthesis, New Synthetic Methodology, Exploratory Chemistry, Bioorganic Chemistry

这项工作将集中在一个多样化的群体的全面综合 关于重要天然产品和开发新的 综合方法学 合成目标包括： 酸、微雌酚、芍药苷、前列腺素H2、乳囊素、 卵蒜素、黄曲霉苷、地棘蛙素和布雷菲德菌素A。 的 选择的方法学主题包括： 乙烯基和炔基转化为醛和酮， 酮的对映选择性还原，手性化合物的合成 环氧乙烷，新手性控制基团的催化合成， 手性氧氮杂铝烷和手性 阳离子恶唑硼烷，新钛的探索性研究 (IV)络合物作为对映选择性催化剂的应用 用于对映选择性合成的衍生催化剂和新的 制备中、大环的方法 萜类 %%% 有了这个更新奖，合成有机计划是 支持该部门的Elias J. Corey博士的研究 哈佛大学的化学教授 科里教授将专注于 他的工作是合成几种天然存在的， 生物活性复杂有机分子。他还将 开发新的合成方法

This work will focus on the total synthesis of a diverse group of important natural products and on the development of new synthetic methodology. Synthetic targets include: oleanolic acid, miroestrol, paeoniflorin, prostaglandin H2, lactacystin, ovalicin, cassioside, epibatidine and brefeldin A. The methodology topics chosen include: enantioselective addition of vinyl and alkynyl groups to aldehydes and ketones, enantioselective reduction of ketones, syntheses of chiral oxiranes, catalytic syntheses of new chiral controller groups, exploratory chemistry of chiral oxazaaluminolidines and chiral cationc oxazaborolidines, exploratory research on new titanium (IV) complexes as enantioselective catalysts, use of amino-acid derived catalysts for enantioselective synthesis and new methodology for the preparation of medium- and large-ring terpenoids. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Elias J. Corey of the Department of Chemistry at Harvard University. Professor Corey will focus his work on the synthesis of several naturally occurring and biologically active complex organic molecules. He will also pursue the development of new synthetic methodology