Deciphering the rules of T cell residency across intestinal compartments

破译 T 细胞在肠腔内的驻留规则

• 批准号: DE230100084
• 负责人: Dr Maximilien Evrard
• 金额: $ 33.24万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100084
• 关键词: Deciphering; rules; cell; residency; across

Tissue-resident memory T cells (TRM) are key for immune protection against infection and cancer at barrier sites including the gut. Whilst much of our understanding of gut TRM comes from studies on the small intestine, how these cells develop and function in the large intestine is unknown. Using state-of-the-art techniques and novel animal models, this project aims to (i) identify molecular pathways by which the local intestinal microenvironment influences TRM development and (ii) how these pathways could modulate TRM generation specifically in the small or large intestine. The expected outcomes are to generate fundamental new knowledge that will have significance for regulation of the immune response.

组织驻留记忆T细胞（TRM）是在包括肠道在内的屏障部位抵抗感染和癌症的免疫保护的关键。虽然我们对肠道TRM的了解大多来自于对小肠的研究，但这些细胞在大肠中的发育和功能尚不清楚。利用最先进的技术和新颖的动物模型，该项目旨在(i)确定局部肠道微环境影响TRM发展的分子途径，以及（ii）这些途径如何在小肠或大肠中特异性地调节TRM的产生。预期的结果是产生基本的新知识，对免疫反应的调节具有重要意义。