Deciphering the rules of T cell residency across intestinal compartments

组织驻留记忆T细胞(TRM)是免疫保护包括肠道在内的屏障部位免受感染和癌症的关键。虽然我们对肠道TRM的大部分了解来自对小肠的研究，但这些细胞在大肠中如何发育和功能尚不清楚。利用最先进的技术和新颖的动物模型，该项目旨在(I)确定局部肠道微环境影响TRM发育的分子途径，以及(Ii)这些途径如何调节特定的小肠或大肠TRM的产生。预期的结果是产生基本的新知识，这些知识将对免疫反应的调节具有重要意义。

Tissue-resident memory T cells (TRM) are key for immune protection against infection and cancer at barrier sites including the gut. Whilst much of our understanding of gut TRM comes from studies on the small intestine, how these cells develop and function in the large intestine is unknown. Using state-of-the-art techniques and novel animal models, this project aims to (i) identify molecular pathways by which the local intestinal microenvironment influences TRM development and (ii) how these pathways could modulate TRM generation specifically in the small or large intestine. The expected outcomes are to generate fundamental new knowledge that will have significance for regulation of the immune response.