Achaete-Scute Genes and Neural Differentiation in the Hindbrain

93-09803温伯格神经系统从一美元起发育出多种类型的细胞！。！。好了！F一组看似同质的细胞。负责发展这些不同类型细胞的机制仍然知之甚少。已经确定了一个基因家族，其蛋白质产物似乎参与了这一过程。最近确定了这个家族的两个新成员，并将在这个项目中进一步分析。这些基因在发育中的后背非常特定的区域表达。这些区域包含在这些基因首次表达后不久就会发育成神经元的细胞。该项目将寻求识别表达这些基因的特定细胞，并确定这些基因的表达是否是这些细胞特定命运发展的先决条件。这个项目应该会在理解后脑发育方面取得重大进展，并将为神经系统中如何产生不同类型的细胞这一更普遍的问题提供新的见解。！。！。！。！。！。！。！。！。(Times New Roman符号&amp；Arial o D J d N O@“$$”h j et eq e C Weinberg William Proctor，IBN William Proctor，IBN William Proctor，IBN

93-09803 Weinberg The nervous systems develops a myriad of cell types from $ !. !. ! F a seemingly homogeneous population of cells. The mechanisms responsible for developing these different cell types are still poorly understood. A family of genes, achaete-scute homologues, have been identified whose protein products appear to be involved in this process. Two new members of this family have recently been identified and will be further analyzed in this project. These genes are expressed in very specific regions of the developing hindbra in. These regions contain cell that will develop neurons shortly after these genes are first expressed. This project will seek to identify the specific cells that express these genes and to determine whether expression of these genes is a prerequisite for development of the specific fates of these cells. This project should make significant inroads into understanding hindbrain development and will offer new insights into the more general question of how different cell types arise in the nervous system $ $ " $ !. !. !. !. !. !. !. !. !. ( Times New Roman Symbol & Arial o o o D J d N O @ " $ $ " h j et eq e C weinberg William Proctor, IBN William Proctor, IBN