Glial-Neuronal Interactions in the Superior Cervical Ganglion

颈上神经节的胶质神经元相互作用

• 批准号: 9310511
• 负责人: Alison Hall
• 金额: $ 12.26万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9310511&HistoricalAwards=false
• 关键词: Glial; Neuronal; Interactions; Superior; Cervical

9310511 Hall The nervous system is composed of two major cell types, neurons and glia. Glial cells have many important roles that allow the neurons to function. Different types of glial cells have different functions and are needed in different parts of the nervous system. Little is known about how the different glial cell types arise during development of the nervous system. This study will define how neurons alter glial cells during the development, and will establish the similarities and differences between two types of glial cells, those of nerves and those of ganglia. The hypothesis to be tested is that glial cell precursors divide and mature into either of these two types of glia in response to factors from the neurons. A cell culture system has been developed that will allow this hypothesis to be tested. Information from these studies will lead to a greater understanding of how cell-cell interactions influence development in the normal nervous system. *** 9310511 Hall The nervous system is composed of two major cell types, neurons and glia. Glial cells have many important roles T Y ! ! F ( Times New Roman Symbol & Arial " h C ? ? hall William Proctor, IBN William Proctor, IBN

9310511大厅 神经系统由两种主要的细胞类型组成，神经元和神经胶质。神经胶质细胞有许多重要的作用，使神经元的功能。不同类型的神经胶质细胞具有不同的功能，并且在神经系统的不同部分中需要。 关于神经系统发育过程中不同类型的胶质细胞是如何产生的知之甚少。这项研究将定义神经元如何在发育过程中改变神经胶质细胞，并将建立两种类型的神经胶质细胞，神经和神经节之间的相似性和差异。待检验的假设是神经胶质细胞前体细胞响应于来自神经元的因子而分裂并成熟为这两种类型的神经胶质细胞中的任一种。 已经开发了一种细胞培养系统，可以测试这一假设。这些研究的信息将使我们更好地理解细胞间相互作用如何影响正常神经系统的发育。 *** 9310511大厅 神经系统由两种主要的细胞类型组成，神经元和神经胶质。神经胶质细胞有许多重要的作用 不 Y ! ! F ( Times New Roman 符号Arial " H C ? ? 大厅 William普罗克特，IBN William普罗克特，IBN