U.S.-Mexico: Hydrolysis of Phosphate Esters

美国-墨西哥：磷酸酯的水解

• 批准号: 9313268
• 负责人: Ludwik Adamowicz
• 金额: $ 2.56万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-15 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9313268&HistoricalAwards=false
• 关键词: U.S.; Mexico; Hydrolysis; Phosphate; Esters

9313268 Adamowicz This U.S.-Mexico award will support a collaboration between Professor Ludwik Adamowicz of the University of Arizona and Professor Ivan Ortega Blake of the Institute of Physics of the National Autonomous University of Mexico (UNAM) in Cuernavaca, Mexico. The collaborators intend to work on the hydrolysis of phosphate esters using a combination of ab initio quantum theory, molecular dynamics, and molecular modeling. The goal of the study is to elucidate the molecular mechanisms as well as determine the most effective mediators which enhance or inhibit phosphate bond hydrolysis. The importance of the phosphate bond can hardly be overestimated. Its critical role in biological systems in constantly upgraded: it is not only relevant to the process of ATP synthesis and hydrolysis, but also there is increasing evidence of it being involved in all sorts of processes through phosphorylation/dephosphorylation, and as a trigger mechanism in multiple second phenomena. The proposed work will be conducted as a collaborative effort through mutual contacts, visits, a student exchange program, and electronic communication. The long term goal of the project is to advance our understanding of a crucial biological process as a source of bioenergy. ***

9313268 Adamowicz美国-墨西哥奖将支持亚利桑那大学Ludwik Adamowicz教授和墨西哥库埃尔纳瓦卡墨西哥国立自治大学物理研究所Ivan Ortega Blake教授之间的合作。 合作者打算使用从头算量子理论，分子动力学和分子建模的组合来研究磷酸酯的水解。 该研究的目的是阐明分子机制，以及确定最有效的介质，增强或抑制磷酸键水解。 磷酸键的重要性怎么估计也不过分。 它在生物系统中的关键作用在不断升级：它不仅与ATP的合成和水解过程有关，而且越来越多的证据表明它通过磷酸化/去磷酸化参与各种过程，并作为多个第二现象的触发机制。拟议的工作将通过相互联系，访问，学生交流计划和电子通信作为一种合作努力进行。 该项目的长期目标是促进我们对作为生物能源来源的关键生物过程的理解。 ***