Sorption of Ionized and Un-Ionized Species of Chlorinated Phenols, Catechols and Guaiacols on Lipid Membranes. Are Octanol-Water Partition Coefficients Applicable?

本研究的目的是解决的有效性辛醇-水分配测量的基础上，估计生物群和周围的水环境中的某些污染物的毒性和分布。 提出将造纸产品氯化芳基醇吸附到脂质体上，以作为更有代表性的生物组织模型。 将根据浓度、pH值和盐浓度进行测量。 将测定离子化和非离子化物质的结果，并与辛醇-水分配系数进行比较。 要检查吸附和游离毒素之间的酸解离常数的离散性。 这项研究的结果将有助于确定污染物的命运，估计毒性水平，并在评估使用生物质去除这些类型的污染物。

This research aims to address the validity of octanol-water partition measurements as a basis for estimating the toxicity and distribution of certain pollutants between biota and surrounding aqueous environment. Sorption of chlorinated aryl alcohols, products of paper manufacture, onto liposomes is proposed for a more representative model of biological tissues. Measurements will be made as a function of concentration, pH and salt concentration. Results for ionized and un-ionized species will be determined and compared with the octanol-water partition coefficients. Discrepancies of acid dissociation constants between the sorbed and free toxins is to be examined. Results from this research will be helpful in determining the fate of pollutants, estimating toxicity levels, and in evaluating the use of biomass for the removal of these types of pollutants.