Sorption of Ionized and Un-Ionized Species of Chlorinated Phenols, Catechols and Guaiacols on Lipid Membranes. Are Octanol-Water Partition Coefficients Applicable?

本研究旨在解决辛醇-水分配测量的有效性，作为估计某些污染物在生物群和周围水环境之间的毒性和分布的基础。氯化芳香醇的吸附，造纸产品，到脂质体提出了一个更有代表性的生物组织模型。测量将作为浓度，pH值和盐浓度的函数。将用辛醇-水分配系数来测定电离和未电离物质的结果。要检查吸附毒素和游离毒素之间的酸解离常数的差异。这项研究的结果将有助于确定污染物的命运，估计毒性水平，并评估利用生物质去除这些类型的污染物。

This research aims to address the validity of octanol-water partition measurements as a basis for estimating the toxicity and distribution of certain pollutants between biota and surrounding aqueous environment. Sorption of chlorinated aryl alcohols, products of paper manufacture, onto liposomes is proposed for a more representative model of biological tissues. Measurements will be made as a function of concentration, pH and salt concentration. Results for ionized and un-ionized species will be determined and compared with the octanol-water partition coefficients. Discrepancies of acid dissociation constants between the sorbed and free toxins is to be examined. Results from this research will be helpful in determining the fate of pollutants, estimating toxicity levels, and in evaluating the use of biomass for the removal of these types of pollutants.