The Bicaudal-D function in RNA localization

9320283 Steward定位卵母细胞和早期胚胎中的决定因素代表了非洲爪哇和果蝇胚胎模式形成的基本步骤。在这两种生物中，决定因素的定位都是通过信使核糖核酸靶向来实现的。虽然已经在果蝇和非洲爪哇中发现并研究了几个定位的RNA，但导致这种定位的机制在很大程度上还不清楚。Bicaudal-D蛋白在卵子发生过程中对mRNAs的定位起作用。在卵子发生的早期，它似乎是从囊细胞运输到原卵母细胞。它可能在卵母细胞内RNA的运输或拴系中发挥作用。斯图尔特博士建议进行实验，以解决这些基本问题：Bic-D如何发挥作用来定位RNA？定位的Bic-D RNA的功能是什么？哪些因素与Bic-D RNA中的RNA定位序列相互作用以实现其定位？*

9320283 Steward Localization of determinants in the oocyte and the early embryo represents a fundamental step in embryonic patterning in both Xenopus and Drosophila. In both organisms the localization of determinants is achieved through mRNA targeting. While several localized RNAs have been identified and studied in Drosophila and in Xenopus, the mechanisms responsible for this localization are largely unknown. The Bicaudal-D protein plays a role in the localization of mRNAs during oogenesis. It appears to be transported from the cystocytes to the pro-oocyte in early oogenesis. It may function either in the transport or tethering of RNAs in the oocyte. Dr. Steward proposes experiments addressing these basic questions: How does Bic- D function to localize RNAs? What is the function of the localized Bic-D RNA, and what factors interact with the RNA localization sequences in the Bic-D RNA to achieve its localization? ***