Investigations of the drug and organic anion transporter ABCC4

药物和有机阴离子转运蛋白 ABCC4 的研究

• 批准号: 200903
• 负责人: Cole Susan P
• 金额: $ 48.34万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2015-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200903&lang=en
• 关键词: Cancer Chemotherapy; Drug And Organic Anion Transport; Drug Disposition; Gene Regulation; Membrane Protein Trafficking; Multidrug Resistance Protein

There are many factors that determine both the effectiveness and toxicity (adverse side effects) of drugs. In the case of an anticancer drug, this is largely determined by how much of the drug is able to reach the tumour (desired target) versus how much d

决定药物有效性和毒性(副作用)的因素有很多。在抗癌药物的情况下，这在很大程度上取决于药物的多少能够到达肿瘤(所需的靶点)，而不是多少。