Marine Biotech Fellowship: Natural Products from Common Shallow-water Soft Corals of Guam: Reproductive Considerations

海洋生物技术奖学金：关岛常见浅水软珊瑚的天然产物：繁殖考虑因素

• 批准号: 9321533
• 负责人: Marc Slattery
• 金额: --
• 依托单位: University of Guam
• 依托单位国家: 美国
• 项目类别: Fellowship
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9321533&HistoricalAwards=false
• 关键词: Marine; Biotech; Fellowship; Natural; Products

9321533 Slattery The proposed research program will utilize analytical chemistry techniques to evaluate the importance of secondary metabolites and steroids in reproduction of the soft corals Lobophytum spp., Sarcophyton spp., Sinularia spp., and Stereonephthya spp. from Guam. It is a continuation of an ongoing project which has identified and examined the importance of secondary metabolites, organic extracts, and morphological defenses in soft coral predator deterrence. This research will expand upon the aforementioned program to extract, isolate, and determine the structures of new secondary metabolites in adult colonies and their eggs. Temporal changes in concentrations of these compounds will be correlated with reproductive indices to assess the role of the compounds in maturation and spawning. Standard bioassays will be conducted to guide isolation natural products in egg release, sperm chemotaxis, and feeding deterrence. Novel compounds identified in this project will expand upon a growing database of metabolites that can be used as chemotaxonomic markers and will be incorporated into existing pharmacological programs. Furthermore, this project will contribute significant insights into the reproductive biology and chemical ecology of the common soft corals on the shallow reefs surrounding Guam. ***

9321533斯莱特里拟议的研究计划将利用分析化学技术，以评估次级代谢产物和类固醇在软珊瑚Lobophytum spp.，肉癣菌属，Sinularia spp.，和Stereonephthya spp.从关岛。这是一个正在进行的项目，已确定和检查的重要性，次级代谢产物，有机提取物，和形态防御软珊瑚捕食者威慑的延续。这项研究将扩大上述计划，以提取，分离和确定成年群体及其卵中新的次级代谢产物的结构。这些化合物浓度的时间变化将与生殖指数相关，以评估化合物在成熟和产卵中的作用。将进行标准的生物测定，以指导分离天然产物在卵子释放，精子趋化性和喂养威慑。在这个项目中发现的新化合物将扩大一个不断增长的代谢物数据库，这些代谢物可用作化学分类学标记，并将被纳入现有的药理学计划。此外，该项目将有助于深入了解关岛周围浅礁上常见软珊瑚的生殖生物学和化学生态学。***