Developing CRISPR Prime Editing for highly efficient precise gene editing

开发 CRISPR Prime 编辑以实现高效精确的基因编辑

• 批准号: DE230101081
• 负责人: Dr Fatwa Adikusuma
• 金额: $ 32.29万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101081
• 关键词: Developing; CRISPR; Prime; Editing; highly

This project will further develop a recent breakthrough in gene editing technology named CRISPR prime editing to improve its performance in generating specific genome modifications in cells and organisms. This project expects to generate new knowledge regarding optimal strategies for its deployment as well as create novel enhanced versions of the technology. This would significantly enhance our ability to perform precise genome modification of organisms and lead to substantial benefits for a vast array of applications in fundamental and applied biology. Future applications will include generating mutations in cells and model organisms for basic research and creating genetically enhanced agricultural animals or plants.

该项目将进一步发展最近在基因编辑技术方面取得的突破，即CRISPR prime editing，以提高其在细胞和生物体中产生特定基因组修饰的性能。该项目预计将产生有关其部署的最佳策略的新知识，并创建该技术的新增强版本。这将大大提高我们对生物体进行精确基因组修饰的能力，并为基础生物学和应用生物学的大量应用带来实质性好处。未来的应用将包括为基础研究在细胞和模式生物中产生突变，以及创造基因增强的农业动物或植物。