Inducible metabolism of xenochemicals and endogenous toxic compounds: nuclear receptors and the CYP2B paradigm

异种化学物质和内源性有毒化合物的诱导代谢：核受体和 CYP2B 范式

• 批准号: 212079
• 负责人: Anderson Alan
• 金额: $ 34.63万
• 依托单位: Centre Hospitalier Universitaire de Qubec
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=212079&lang=en
• 关键词: Cancer; Cyp2b Genes; Cytochrome P450; Inducible Drug Metabolism; Nuclear Receptors; Phenobarbital

Cytochrome P450s are key enzymes in the modification of drugs and other foreign small molecules within the body. They form an essential part of a system that modifies an extraordinary diversity of substances. The normal biological role of cytochrome P450s

细胞色素P450是体内药物和其他外来小分子修饰的关键酶。它们构成了一个系统的重要组成部分，这个系统改变了异常多样的物质。细胞色素P450的正常生物学作用