NATO EAST EUROPE: Activation of Ca 2+ Release Channels in Sacroplasmic Reticulum from Skeletal and Heart Muscles by Free Radicals

北约东欧：自由基激活骨骼肌和心肌骶浆网中的 Ca 2 释放通道

• 批准号: 9355516
• 负责人: Valerian Kagan
• 金额: $ 0.38万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-10-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9355516&HistoricalAwards=false
• 关键词: NATO; EAST; EUROPE; Activation; Ca

9355516 Kagan Dr. V. Kagan is a faculty member at the Department of Environmental and Occupational Health at the University of Pittsburgh. He is a world recognized leader in the field of free radical and antioxidant research. His current research program includes extensive ESR studies of free radical mechanisms involved in the activation of Ca2+ release channels in sarcoplasmic reticulum membranes. Dr. V. Ritov is the Associate Research Professor of Biochemistry at the Department of Biology, State University of Moscow. With his systematic studies of Ca2+ transport and mechanisms of its regulation, he has gained an outstanding reputation as a biochemist. The presence of Dr. Ritov in Dr. Kagan's laboratory at the University of Pittsburgh on a daily basis will greatly facilitate the joint studies on the involvement of free radicals and antioxidants in fundamental physiologic mechanisms of functioning of Ca2+-release channel in sarcoplasmic reticulum membranes. Dr. V. Ritov will have access to unique ESR techniques for free radical studies developed in Dr. Kagan's laboratory which he will be able to use in his research upon his return to Russia. Dr. Ritov's visit to the US will enable him to interact with American scientists directly and will enhance his international scientific reputation that he deserves. The visit of Dr. V. Ritov to Dr. Kagan's laboratory will significantly strengthen the collaborative research in their laboratories both in the US and in Russia. ***

9355516卡根V. Kagan博士是匹兹堡大学环境与职业健康系的教员。 他是自由基和抗氧化剂研究领域的世界公认领导者。 他目前的研究计划包括广泛的ESR研究参与激活肌浆网膜中的Ca2+释放通道的自由基机制。 V. Ritov博士是莫斯科州立大学生物系生物化学副研究教授。 由于他对Ca2+运输及其调节机制的系统研究，他作为生物化学家获得了杰出的声誉。 Ritov博士每天在匹兹堡大学Kagan博士的实验室的存在将极大地促进自由基和抗氧化剂参与肌浆网膜中Ca2+释放通道功能的基本生理机制的联合研究。 V. Ritov博士将有机会获得卡根博士实验室开发的用于自由基研究的独特ESR技术，他将能够在返回俄罗斯后在研究中使用这些技术。 Ritov博士对美国的访问将使他能够直接与美国科学家互动，并将提高他应得的国际科学声誉。 Ritov博士对Kagan博士实验室的访问将大大加强他们在美国和俄罗斯实验室的合作研究。 ***