Structure and Mechanism of an E2-E3 Enzyme Complex in Ubiquitylation

E2-E3酶复合物泛素化的结构和机制

• 批准号: 225407
• 负责人: Spratt Donald E
• 金额: $ 3.28万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-02-01 至 2012-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=225407&lang=en
• 关键词: E2 Enzyme; E3 Enzyme; Nmr Spectroscopy; Protein Structure; Protein-Protein Interations; Ubiquitylation

Cells grow and divide through a delicate balance between the synthesis of proteins to signal and carry out the replication of DNA, and the degradation of these same proteins. If this balance is altered such that the degradation of some proteins is either

细胞生长和分裂通过蛋白质的合成之间的微妙平衡来发出信号并进行DNA的复制，以及这些相同蛋白质的降解。如果这种平衡被改变，使得某些蛋白质的降解