Chemistry and Synthetic Applications of Alpha-Aminoalkylcuprates

α-氨基烷基铜酸盐的化学与合成应用

• 批准号: 9408912
• 负责人: R. Karl Dieter
• 金额: $ 26.9万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9408912&HistoricalAwards=false
• 关键词: Chemistry; Synthetic; Applications; Alpha; Aminoalkylcuprates

9408912 The focus of this research will be to develop methods using the 1,4-conjugate addition chemistry of alpha-aminoalkylcuprates to prepare useful synthetic intermediates in ways that are both diastereoselective and enantioselective. The methodology will be showcased in the synthesis of nine representative alkaloids. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. R. Karl Dieter of the Department of Chemistry at Clemson University. Professor Dieter will focus his work on developing a new organometallic reagents known as an alpha-aminoalkylcuprates. The reagents will then be used for the synthesis of representative natural products from the class of compounds referred to as alkaloids.

9408912这项研究的重点将是开发使用α-氨基烷基铜酸盐的1，4-共轭加成化学的方法，以非对映选择性和对映体选择性的方式制备有用的合成中间体。该方法将在九种具有代表性的生物碱的合成中得到展示。%有了这个续期奖，合成有机计划支持克莱姆森大学化学系的R.Karl Dieter博士的研究。迪特尔教授将专注于开发一种新的有机金属试剂，即α-氨基烷基铜酸盐。然后，这些试剂将用于从生物碱类化合物中合成具有代表性的天然产物。