Chemistry and Synthetic Applications of Alpha-Aminoalkylcuprates

9408912 本研究的重点将是开发使用α-氨基烷基铜酸盐的1，4-共轭加成化学以非对映选择性和对映选择性的方式制备有用的合成中间体的方法。 该方法将展示在九个代表性生物碱的合成。 有了这个更新的奖项，合成有机计划正在支持R博士的研究。克莱姆森大学化学系的卡尔·迪特尔说。 Dieter教授将专注于开发一种新的有机金属试剂，称为α-氨基烷基铜酸盐。 然后，这些试剂将用于合成来自被称为生物碱的化合物类别的代表性天然产物。

9408912 The focus of this research will be to develop methods using the 1,4-conjugate addition chemistry of alpha-aminoalkylcuprates to prepare useful synthetic intermediates in ways that are both diastereoselective and enantioselective. The methodology will be showcased in the synthesis of nine representative alkaloids. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. R. Karl Dieter of the Department of Chemistry at Clemson University. Professor Dieter will focus his work on developing a new organometallic reagents known as an alpha-aminoalkylcuprates. The reagents will then be used for the synthesis of representative natural products from the class of compounds referred to as alkaloids.