Research Initiation Award: In Vitro Study of Air Flow and Transport Processes Within the Human Upper Respiratory Tract

9409429 Zhang本RIA中提出的研究是对整个人体上呼吸道内的呼吸流动和运输过程进行计算机模拟研究，包括鼻和口呼吸道、喉呼吸道和前三代气管支气管树。 将气道级联，并在集成呼吸系统中进行计算机模拟。 将通过在三维曲线坐标系中数值求解相应的完整Navier-Stokes方程来研究气道系统内的流型。 将采用贴体网格结合网格封锁法来模拟复杂的气道几何形状。 一个统一的轨迹映射方法将被用来计算粒子的轨迹。 ***

9409429 Zhang The research proposed in this RIA is a computer simulation study of the respiratory flow and transport processes within the entire human upper airways, including nasal and oral airways, laryngeal airway, and first three generation of tracheobronchial tree. Airways will be cascaded and computer simulation will be conducted in the integrated respiratory system. Flow patterns within the airway system will be investigated by numerically solving the corresponding full Navier-Stokes equations in a three- dimensional curvilinear coordinated system. Body-fitted grids in conjunction with the grid block-off method will be employed to mimic the complex airway geometry. A unified trajectory mapping approach will be used to compute particle trajectories. ***