Research Initiation Award: In Vitro Study of Air Flow and Transport Processes Within the Human Upper Respiratory Tract

9409429 Zhang本RIA提出的研究是对整个人体上呼吸道的呼吸流动和运输过程的计算机模拟研究，包括鼻、口气道、喉气道和前三代气管支气管树。气道将被级联，计算机模拟将在综合呼吸系统中进行。通过在三维曲线坐标系中数值求解相应的全Navier-Stokes方程来研究气道系统内的流动模式。将采用与网格块关闭方法相结合的贴体网格来模拟复杂的气道几何形状。将使用统一的轨迹映射方法来计算粒子轨迹。＊＊＊

9409429 Zhang The research proposed in this RIA is a computer simulation study of the respiratory flow and transport processes within the entire human upper airways, including nasal and oral airways, laryngeal airway, and first three generation of tracheobronchial tree. Airways will be cascaded and computer simulation will be conducted in the integrated respiratory system. Flow patterns within the airway system will be investigated by numerically solving the corresponding full Navier-Stokes equations in a three- dimensional curvilinear coordinated system. Body-fitted grids in conjunction with the grid block-off method will be employed to mimic the complex airway geometry. A unified trajectory mapping approach will be used to compute particle trajectories. ***