Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism

该项目旨在识别和验证疟疾寄生虫中易受反应劫持抑制的腺苷形成酶。这类酶可以通过一种新的机制被诱导合成它们自己的核苷磺酸酯抑制剂结合物。该项目有望提供有关这种新的抑制机制的分子基础和寄生虫中易受感染的靶标酶的新知识。腺苷形成酶在多种生化途径中起着关键作用，如蛋白质翻译和脂肪酸代谢。该项目寻求为未来的抗寄生虫剂的设计提供一种新的范例。

This project aims to identify and validate the adenylate-forming enzymes that are susceptible to reaction-hijacking inhibition in malaria parasites. This class of enzymes can be induced to synthesise their own nucleoside sulfamate inhibitor conjugates via a novel mechanism. This project expects to provide new knowledge about the molecular basis of this novel inhibition mechanism and susceptible target enzymes in the parasites. Adenylate-forming enzymes play critical roles in a diverse range of biochemical pathways, such as protein translation and fatty acid metabolism. The project seeks to deliver a new paradigm for the design of future antiparasitic agents.