Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism

通过新的反应劫持机制抑制腺苷酸形成酶

• 批准号: DE230101173
• 负责人: Dr Stanley Cheng Xie
• 金额: $ 26.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101173
• 关键词: Inhibiting; adenylate; forming; enzymes; via

This project aims to identify and validate the adenylate-forming enzymes that are susceptible to reaction-hijacking inhibition in malaria parasites. This class of enzymes can be induced to synthesise their own nucleoside sulfamate inhibitor conjugates via a novel mechanism. This project expects to provide new knowledge about the molecular basis of this novel inhibition mechanism and susceptible target enzymes in the parasites. Adenylate-forming enzymes play critical roles in a diverse range of biochemical pathways, such as protein translation and fatty acid metabolism. The project seeks to deliver a new paradigm for the design of future antiparasitic agents.

本项目旨在鉴定和验证疟原虫中易受反应劫持抑制的腺苷酸形成酶。这类酶可以通过一种新的机制诱导合成它们自己的核苷磺酸盐抑制剂缀合物。本项目旨在为这种新型抑制机制的分子基础和寄生虫的易感靶酶提供新的知识。腺苷酸形成酶在多种生物化学途径中发挥关键作用，如蛋白质翻译和脂肪酸代谢。该项目旨在为未来抗寄生虫剂的设计提供一个新的范例。