Structure in Biology and Chemistry

生物学和化学中的结构

• 批准号: 9413510
• 负责人: William le Noble
• 金额: $ 61万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9413510&HistoricalAwards=false
• 关键词: Structure; Biology; Chemistry

This award from the Academic Research infrastructure Program will help the Department of Chemistry at SUNY-Stony Brook acquire a 500 MHz NMR, and an upgrade of an AMX 600 MHz NMR to a DMX600 MHz NMR which will be used in research. The research activity to be supported includes the structural investigations of five major users who work in organic chemistry and in biological chemistry; the research includes studies of steroidal diamines as DNA-targeted antibiotics, of electronic effects in face selection in addition and elimination processes, of applications of the -lactam synthon method and of 4+4 photocycloaddition processes in approaches to taxol analogs, and of the configurations of synthetic oxidosqualene cyclase and squalene epoxidase inhibitors. Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, charcterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.

这项来自学术研究基础设施计划的奖项将帮助纽约州立大学石溪分校化学系获得500 MHz NMR，并将AMX 600 MHz NMR升级为DMX 600 MHz NMR，用于研究。 拟支助的研究活动包括对从事有机化学和生物化学工作的五个主要用户进行结构调查;该研究包括甾体二胺作为DNA靶向抗生素的研究、加成和消除过程中面选择的电子效应的研究、-内酰胺合成子方法和4+4光环加成过程在紫杉醇类似物方法中的应用，以及合成氧化角鲨烯环化酶和角鲨烯环氧酶抑制剂的构型。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。 它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振光谱法至关重要。 这些NMR研究的结果在聚合物和催化以及生物学等领域都很有用。