Studies of Phase Conjugate Microscopy for Image Processing and Optical Trapping of Microscopic Objects for Biomedical Applications

用于生物医学应用的显微物体图像处理和光学捕获的相位共轭显微镜研究

• 批准号: 9413956
• 负责人: Guann Li
• 金额: $ 30.17万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9413956&HistoricalAwards=false
• 关键词: Studies; Phase; Conjugate; Microscopy; Image

9413956 Sonek The investigators propose to study and quantify the effects of optical phase conjugation on optical trapping, and to design, develop, and evaluate an optimum configuration for the integration of various image processing functions, such as aberration correction, contrast reversal, and novelty filtering, with an optical tweezer and microscopic imaging, for the imaging and diagnosis of micromanipulated biological samples such as cells and tissues. This approach can offer substantially improved imaging capabilities via contrast enhancement of phase objects; high- resolution (submicron) detection and feature extraction of images obscured by aberrating media; preferential display of slow and fast moving objects; rapid nearly all-optical processing of image data; and the simultaneous optical manipulation and force transduction of biological samples. ***

研究人员提出研究和量化光学相位共轭对光阱的影响，并设计、开发和评估用于集成各种图像处理功能的最佳配置，例如像差校正、对比度反转和新奇滤波，以及光镊和显微成像，用于显微操作的生物样品如细胞和组织的成像和诊断。 这种方法可以通过相位对象的对比度增强、被畸变介质遮蔽的图像的高分辨率（亚微米）检测和特征提取、缓慢和快速移动对象的优先显示、图像数据的快速几乎全光学处理以及生物样品的同时光学操纵和力转换来提供显著改进的成像能力。 ***