Conference on Metal and Oxygen Regulation of Gene Expression to be held March 18-24, 1995, Park City, UT

基因表达的金属和氧调节会议将于 1995 年 3 月 18-24 日在犹他州帕克城举行

• 批准号: 9414161
• 负责人: Anne Summers
• 金额: $ 0.5万
• 依托单位: Keystone Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 1996-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9414161&HistoricalAwards=false
• 关键词: Conference; Metal; Oxygen; Regulation; Gene

9414161 Summers The 1995 Keystone Symposium METAL AND OXYGEN REGULATION OF GENE EXPRESSION will be held March 18 - March 24 at Park City, Utah. Although the sub-discipline of biochemistry called "metallo-enzymology" has recognized since early in this century a role for metals in certain biological catalyses, it is only in the last 12 - 14 years that the pervasive role of metals in every aspect of cellular function has come more widely to light. This new appreciation of metallo-biochemistry or bio-organic chemistry is largely a result of advances in biophysics and chemical spectroscopy which allow sophisticated assessment of the behavior of metals with a variety of biological ligands, from proteins or their prosthetic groups to nucleic acids and carbohydrates. The information gathered through this new observational and analytic power suggests that all significant biological processes are influenced by metals at some stage. Moreover, this information understanding is not simply of academic interest, as certain metals have already proven to be potent anti-tumor agents and powerful tools for analysis and manipulation of biomolecules. Similarly, we are at a watershed in our appreciation of the role of oxygen compounds and intermediates in biology. While always seen as essential for higher forms of life, oxygen and its metabolites have been more recently recognized as key players in development, host defense mechanisms, neoplasia, and aging. Since the discovery of the mechanism of hemoglobin, oxygen metabolism has been clearly associated with metal chemistry. In intervening decades much more of the enzymology of oxygen metabolism (as well as that of other biologically important gases including nitrogen, nitric oxide, carbon monoxide, carbon dioxide) has been shown to involve metals at key steps. This conference is unique in including both metals and oxygen and in focusing on the subject of regulation of gene expression by them. %%% Metals and oxygen play a role in virtually every aspect of ce llular function. Increasingly, these roles are being recognized and studied. The 1995 Keystone Symposium on metal and oxygen regulation of gene expression will bring together researchers in this important and developing field. Genetic regulation by metal and oxygen has significant impact on the environment, agriculture, and health. ***

1995年的基石研讨会金属和氧调控基因表达将于3月18日至3月24日在犹他州帕克城举行。尽管自本世纪初以来，生物化学的分支学科“金属酶学”已经认识到金属在某些生物催化中的作用，但直到最近12 - 14年，金属在细胞功能的各个方面的普遍作用才得到更广泛的认识。这种对金属生物化学或生物有机化学的新认识在很大程度上是生物物理学和化学光谱学进步的结果，这使得金属与各种生物配体（从蛋白质或它们的假基到核酸和碳水化合物）的行为可以进行复杂的评估。通过这种新的观察和分析能力收集到的信息表明，所有重要的生物过程在某些阶段都受到金属的影响。此外，这种信息理解不仅仅是学术上的兴趣，因为某些金属已经被证明是有效的抗肿瘤剂和分析和操纵生物分子的有力工具。同样，我们对氧化合物和中间体在生物学中的作用的认识正处于一个分水岭。氧气及其代谢物一直被认为是高等生命的必要条件，最近人们认识到氧气及其代谢物在发育、宿主防御机制、肿瘤形成和衰老过程中起着关键作用。自从发现血红蛋白的机制以来，氧代谢就明确地与金属化学联系在一起。在这期间的几十年里，更多的氧代谢酶学（以及其他重要的生物气体，包括氮、一氧化氮、一氧化碳、二氧化碳）在关键步骤中都与金属有关。这次会议的独特之处在于既包括金属和氧，又关注它们对基因表达的调节。金属和氧几乎在细胞功能的各个方面都起着作用。这些角色正越来越多地被认识和研究。1995年关于金属和氧调控基因表达的专题讨论会将汇集这一重要和发展中的领域的研究人员。金属和氧的遗传调控对环境、农业和健康有重大影响。＊＊＊