Conference on Metal and Oxygen Regulation of Gene Expression to be held March 18-24, 1995, Park City, UT

9414161萨默斯1995年的基石研讨会金属和氧调节基因表达将于3月18日至3月24日在帕克城，犹他州。虽然生物化学的分支学科“金属酶学”早在20世纪70年代就已经认识到， 尽管金属在某些生物催化中发挥了世纪的作用，但直到最近12 - 14年，金属在细胞功能各个方面的普遍作用才得到更广泛的关注。这种对金属生物化学或生物有机化学的新认识在很大程度上是生物物理学和化学光谱学进步的结果，这些进步允许对金属与各种生物配体的行为进行复杂的评估，从蛋白质或其辅基到核酸和碳水化合物。通过这种新的观察和分析能力收集的信息表明，所有重要的生物过程都在某个阶段受到金属的影响。 此外，这种信息理解不仅仅是学术上的兴趣，因为某些金属已经被证明是有效的抗肿瘤剂和分析和操纵生物分子的强大工具。 同样，我们也正处在理解含氧化合物和中间体在生物学中的作用的分水岭。虽然一直被认为是更高形式的生命所必需的，但氧气及其代谢物最近被认为是发育，宿主防御机制，肿瘤和衰老的关键参与者。自从血红蛋白的机制被发现以来，氧代谢已经明显与金属化学有关。在此期间的几十年里，更多的氧代谢酶学（以及其他生物学上重要的气体，包括氮气，一氧化氮，一氧化碳，二氧化碳）已被证明在关键步骤中涉及金属。 这次会议是独特的，包括金属和氧，并在重点对基因表达的调控，他们的主题。 金属和氧几乎在细胞功能的各个方面都发挥作用。 这些作用正日益得到承认和研究。 1995年关于金属和氧调节基因表达的Keystone研讨会将汇集这一重要和发展中领域的研究人员。 金属和氧气的遗传调节对环境、农业和健康产生重大影响。 ***

9414161 Summers The 1995 Keystone Symposium METAL AND OXYGEN REGULATION OF GENE EXPRESSION will be held March 18 - March 24 at Park City, Utah. Although the sub-discipline of biochemistry called "metallo-enzymology" has recognized since early in this century a role for metals in certain biological catalyses, it is only in the last 12 - 14 years that the pervasive role of metals in every aspect of cellular function has come more widely to light. This new appreciation of metallo-biochemistry or bio-organic chemistry is largely a result of advances in biophysics and chemical spectroscopy which allow sophisticated assessment of the behavior of metals with a variety of biological ligands, from proteins or their prosthetic groups to nucleic acids and carbohydrates. The information gathered through this new observational and analytic power suggests that all significant biological processes are influenced by metals at some stage. Moreover, this information understanding is not simply of academic interest, as certain metals have already proven to be potent anti-tumor agents and powerful tools for analysis and manipulation of biomolecules. Similarly, we are at a watershed in our appreciation of the role of oxygen compounds and intermediates in biology. While always seen as essential for higher forms of life, oxygen and its metabolites have been more recently recognized as key players in development, host defense mechanisms, neoplasia, and aging. Since the discovery of the mechanism of hemoglobin, oxygen metabolism has been clearly associated with metal chemistry. In intervening decades much more of the enzymology of oxygen metabolism (as well as that of other biologically important gases including nitrogen, nitric oxide, carbon monoxide, carbon dioxide) has been shown to involve metals at key steps. This conference is unique in including both metals and oxygen and in focusing on the subject of regulation of gene expression by them. %%% Metals and oxygen play a role in virtually every aspect of ce llular function. Increasingly, these roles are being recognized and studied. The 1995 Keystone Symposium on metal and oxygen regulation of gene expression will bring together researchers in this important and developing field. Genetic regulation by metal and oxygen has significant impact on the environment, agriculture, and health. ***