Anti-Idiotypic Antibodies as Probes of Plant Microtubule- Associated Proteins

小行星9415479 这是一个探索性研究的小补助金。 该项目是对植物中微管相关蛋白（MAP）的一次钓鱼探险，使用基于抗独特型抗体的高风险创新方法作为识别推定MAP的试剂。 在动物系统中，关于微管相关蛋白（MAP），在蛋白质结构和功能方面都有很多了解。 这些MAP在稳定微管和调节微管的组装和拆卸中起着关键作用。 在植物中，尚未实现对任何MAP的普遍接受的鉴定。 由于微管在植物细胞的基本生命过程中起着关键作用，并且由于它们是一类重要的除草剂的作用靶点，因此有令人信服的理由增加我们对植物微管结构和功能的理解，包括识别MAP。 这个项目是一个高风险，但合理的方法来识别植物地图。 ***

9415479 Morejohn This is a Small Grant for Exploratory Research. The project is a fishing expedition for microtubule-associated proteins (MAPs) in plants, using a high-risk, innovative approach based on the production of anti-idiotypic antibodies as reagents for identifying putative MAPs. %%% In animal systems, a lot is known about microtubule- associated proteins (MAPs), in terms of both protein structure and functions. These MAPs play critical roles in stabilizing microtubules and regulating the assembly and disassembly of microtubules. In plants, a generally accepted identification of any MAP has not yet been achieved. Since microtubules play critical roles in the fundamental life processes of plant cells, and since they are the targets of action of an important class of herbicides, there is compelling reason to increase our understanding of microtubule structure and function in plants, including the identification of MAPs. This project is a high-risk but plausible approach to the identification of plant MAPs. ***