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RUI: Brain Mast Cells During Reproduction

RUI：繁殖过程中的脑肥大细胞

基本信息

批准号：
9417557
负责人：
Rae Silver
金额：
$ 5万
依托单位：
Barnard College
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-01 至 1996-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9417557&HistoricalAwards=false
关键词：
RUI Brain Mast Cells During

项目摘要

The Small Grants for Exploratory Research is a mechanism at the National Science Foundation to provide support for small-scale, exploratory, high-risk research in all fields of science. Dr. Silver has found the appearance of non-neuronal cell types in the brain following specific behaviors associated with reproduction. She has presented evidence to suggest that this new population of cells are mast cells of the immune system. Dr. Silver and her students will now examine the appearance of putative mast cells by determining whether they are migrating into the brain in response to appropriate environmental and behavioral stimuli, or whether these cells preexist in the CNS but remain undetectable. She will also examine the influence of behavioral and endocrine state on this population of non-neuronal cells. To accomplish this aim, Dr. Silver and her students will determine whether there is a sexual dimorphism in the distribution and number of putative mast cells and define the role played by gonadal and pituitary hormones in this phenomenon. Finally, she will use state-of-the art anatomical techniques to characterize this population of cells as mast cells and determine whether they possess receptors for steroid and peptide hormones. This research is appropriate for the SGER competition since it will provide strong preliminary work on a novel and exciting idea which opens a completely new direction in the field of behavioral neuroendocrinology. The results could provide a new mechanism for peptide-hormone release in the brain as well as to establish an interrelationship between the immune and neural systems during normally occurring behaviors.

探索性研究小额赠款是国家科学基金会的一项机制，为所有科学领域的小规模、探索性、高风险研究提供支持。银博士发现，在与生殖有关的特定行为之后，大脑中出现了非神经元细胞类型。她提出的证据表明，这种新的细胞群是免疫系统的肥大细胞。银博士和她的学生现在将检查推定的肥大细胞的外观，通过确定它们是否迁移到大脑中响应适当的环境和行为刺激，或者这些细胞是否预先存在于中枢神经系统，但仍然无法检测到。她还将研究行为和内分泌状态对这群非神经元细胞的影响。为了实现这一目标，银博士和她的学生将确定是否有一个假定的肥大细胞的分布和数量的性二型性，并确定性腺和垂体激素在这一现象中所发挥的作用。最后，她将使用最先进的解剖技术来表征这群细胞为肥大细胞，并确定它们是否具有类固醇和肽激素的受体。这项研究适合SGER竞赛，因为它将为一个新颖而令人兴奋的想法提供强有力的初步工作，这在行为神经内分泌学领域开辟了一个全新的方向。这些结果可以为大脑中肽激素的释放提供一种新的机制，并在正常发生的行为中建立免疫和神经系统之间的相互关系。