Enzyme Catalyzed Insertion of Sulfur During Biotin Biosynthesis

生物素生物合成过程中酶催化的硫插入

• 批准号: 9418430
• 负责人: Edward DeMoll
• 金额: $ 28.5万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9418430&HistoricalAwards=false
• 关键词: Enzyme; Catalyzed; Insertion; Sulfur; During

; R o o t E n t r y F |- ı C o m p O b j b W o r d D o c u m e n t O b j e c t P o o l " ı " ı ! " # $ % & ' ( ) * F Microsoft Word 6.0 Document MSWordDoc Word.Document.6 ; F G + ^_ PWV t u tB + G W RPj j D T V t F & * F W r F tB F 9 |9 D( u- ^ & G & G D: ~ " Z ^ & G & G + ^_ PSWV ^ ^ ? u h !j h + 7j h h ! ^ ^ ? u Metabolic Biochemistry Panel Summary PRIVATE Edward DeMoll MCB 9418430 The PI has presented data from a series of excellent preliminary studies on the biosynthesis of biotin. This is a difficult research topic, but one of great importance to the general field of micromolecular biosynthesis. The proposal contains a very interesting series of experiments which should provide a reasonable amount of new data on mechanisms of sulfur insertion into biotin. The panel expressed some concern about the intense competition in this field and the situation that the PI may find himself doing work already completed by others. Nevertheless, the research plan is sound and clearly presented. The panel placed the proposal into the "excellent" category and strongly recommended funding. ....()()))()() Z : phoenix @ S u m m a r y I n f o r m a t i o n ( Oh +' 0 $ H l D h R:\WWUSER\TEMPLATE\NORMAL.DOT Terry Lee McCrimmon Robert Uffen @ @ @ $ ı @ q Microsoft Word 6.0 4 e = e # D D D D D \ f D c p t t t t t t t j Z j E T 3 t t t t t t t p t t t t t t . 6 t t t Metabolic Biochemistry Panel Summary PRIVATE Edward DeMoll MCB 9418430 The PI has presented data from a series of excellent preliminary studies on the biosynthesis of biotin. This is a difficult research topic, but one of great importance to the general field of micromolecular biosynthesis. The proposal contains a very interesting series of experiments which should provide a reasonable amount of new data on mechanisms of sulfur insertion into biotin. The panel expressed some concern about the intense competition in this field and the situation that the PI may find himself doing work already completed by others. Nevertheless, the research plan is sound and clearly presented. The panel placed the proposal into the "excellent" category and strongly recommended funding. ....()()))()() Z : phoenix @ % & . / 0 1 " # j