Does Mechanopluripotency Enhance the Derivation and Expansion of Naive Human Induced Pluripotent Stem Cells?

机械多能性是否能增强天然人类诱导多能干细胞的衍生和扩增？

• 批准号: 355778
• 负责人: Rancourt Derrick E
• 金额: $ 54.06万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2020-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=355778&lang=en
• 关键词: Adherens Junction; Aggregate Culture; Beta-Catenin; Bioprocess Development; Cellular Reprogramming; Fluid Shear; Induced Pluripotency; Mechanotransduction; Pluripotent Stem Cells; Stirred Suspension Bioreactor

Induced pluripotent stem cells (iPSCs) offer huge potential for regenerative medicine. Being pluripotent, they can be differentiated to any cell or tissue in the body. Pluripotency is one component of stemness; the other is the ability to self-renew. In o

诱导多能干细胞（iPSC）为再生医学提供了巨大的潜力。由于具有多能性，它们可以分化为体内的任何细胞或组织。多能性是干性的一个组成部分;另一个是自我更新的能力。在o