Physiology of Microbial Adaptation

9419597丹尼尔斯研究生课程专门从事微生物生物学近年来有所下降，大大减少了在这个重要的研究领域的高级培训的机会。 作为一种方法，以重建微生物生理学的兴趣和开始培养新的科学家，我们建议一个为期三周的夏季课程的主题为“微生物适应机制”。 本课程将包含针对高级研究生和工业科学家的讲座和实验室部分，主要不在微生物生理学研究领域工作。 当前关于微生物适应机制的主题将在教学人员的讲座中进行调查，并由该领域的专家进行介绍。 讲座将涉及：发酵中微生物的适应性反应、全局反应机制、微生物自养的调节、产甲烷菌中的碳代谢以及微生物的生物降解和生物转化。 伴随的实验练习将说明当前的实际问题，在主题领域，并让学生接触到现代实验技术和概念方法。 实验将为学生提供发酵技术，蛋白质和代谢中间体的表征和定量，酶活性测量和基本动力学分析，鉴定受调控基因的遗传方法以及纯化氧敏感蛋白质所需的厌氧技术。 实验室课程将帮助学生准备挑战和扩展他们目前的研究，并在他们的实验系统中采用新的方法。 该课程的内在目标是建立一个微生物生理学领域研究科学家的重要互动社区。 在一个非正式但紧张的科学环境中向学生介绍领先的科学家应该激发兴奋感和社区感，并为年轻和经验丰富的研究人员网络奠定基础。 %%% 微生物生物学的课程在我们的大学里已经减少了。 因此，我们的研究科学家的能力正在减少，以生物为基础的方法来应对环境污染问题，或探索微生物生物圈的新产品，以控制害虫和疾病，或发现和开发新的生物可降解材料。 微生物生理学课程将开始培训科学家和重建对这一领域的兴趣。 为期三周的讲座/实验室课程将向大学和行业申请者开放。 有关微生物适应机制的主题将由该领域的专家讨论。 实验练习将通过动手实验来说明这些主题领域。 本课程的目标是重新获得微生物生理学领域研究科学家的重要互动社区。 ***

9419597 Daniels Graduate programs specializing in Microbial Biology have declined in recent years, greatly reducing the opportunities for advanced training in this important research area. As one way to rebuild interest in Microbial Physiology and begin to train new scientists, we propose a three week summer course focused on the theme "Mechanisms of Microbial Adaptation". The course will contain both lecture and laboratory components targeted to senior level graduate students and industrial scientists not working primarily in microbial physiology research areas. Current topics on the mechanisms of microbial adaptation will be surveyed in lectures by the teaching staff together with presentations by experts in the field. Lectures will address: adaptive response of microorganisms in fermentations, global response mechanisms, regulation of microbial autotrophism, carbon metabolism in methanogens, and biodegradation and bioconversion by microorganisms. The accompanying laboratory exercises will illustrate current practical problems in the topic areas and expose students to modern experimental techniques and conceptual approaches. Experiments will provide the students with skill in fermentation technology, characterization and quantitation of proteins and metabolic intermediates, enzyme activity measurements and basic kinetic analyses, genetic approaches for the identification of regulated genes, and the anaerobic techniques needed to purify oxygen- sensitive proteins. Laboratory sessions will prepare the students to challenge and expand their current research and to undertake new approaches in their experimental systems. The inherent goal of the course is to establish a significant interactive community of research scientists in the field of Microbial Physiology. Introducing students to leading scientists in an informal but intense science setting should stimulate a sense of excitement and community, and set the foundation for a network of younger and exper ienced researchers. %%% Programs in Microbial Biology have declined in our universitites. As a result, the ability of our research scientists is becoming reduced to respond to environmental pollution problems with biologically based methods, or to explore the microbial biosphere for new products for control of insect pests and disease, or to discover and develop novel biodegradable biomaterials. A course in Microbial Physiology will begin to train scientists and rebuild interest in this area. The three week lecture/laboratory course will be open to university and industry applicants. Topics on the mechanisms of microbial adaptation will be discussed by experts in the field. Laboratory excercises will illustrate these topic areas with hands-on experiments. The goal of the course is to regain a significant interactive community of research scientists in the fild of Microbial Physiology. ***