Neural Mechanisms of Dominance Behavior

支配行为的神经机制

• 批准号: 9423846
• 负责人: Donald Edwards
• 金额: $ 26.46万
• 依托单位: Georgia State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1998-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9423846&HistoricalAwards=false
• 关键词: Neural; Mechanisms; Dominance; Behavior

9423846 Edwards The relationship between the brain and behavior is a dynamic two-way interaction. Biologists would like to understand both how the brain generates behaviors, and also how behavioral contexts produce effects on the brain. It is well-known that social behaviors produce effects on the brain (and therefore other behaviors), but the mechanisms for such interactions is largely unknown. In this grant Dr. Edwards and his colleagues will examine how the dominance status of animals impacts the chemistry of the nervous system and the subsequent expression of well-defined behaviors such as escape. The brain chemical serotonin can modify escape behavior. Dr. Edwards group has evidence that serotonin's effects on brain cells mediating escape vary in fundamentally different ways in dominant animals versus subordinate animals. The mechanisms for serotonin's differential effects will be analyzed at the level of identified cells and specific subtypes of the serotonin receptor. This work will provide new inqights into the pathways by which social behavior and brain function interact. ***

9423846 Edwards 大脑和行为之间的关系是动态的双向交互。 生物学家希望了解大脑如何产生行为，以及行为环境如何对大脑产生影响。 众所周知，社会行为会对大脑（以及其他行为）产生影响，但这种相互作用的机制很大程度上是未知的。 在这笔拨款中，爱德华兹博士和他的同事将研究动物的统治地位如何影响神经系统的化学反应以及随后的明确行为（例如逃跑）的表达。 大脑化学物质血清素可以改变逃避行为。 爱德华兹博士小组有证据表明，血清素对介导逃避的脑细胞的影响在主导动物和从属动物中以根本不同的方式存在差异。 血清素不同作用的机制将在已识别的细胞和血清素受体的特定亚型水平上进行分析。 这项工作将为社会行为和大脑功能相互作用的途径提供新的见解。 ***