New Synthetic Methodology for Natural Product Synthesis

天然产物合成的新合成方法

• 批准号: 9424476
• 负责人: Peter Jacobi
• 金额: --
• 依托单位: Wesleyan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-15 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9424476&HistoricalAwards=false
• 关键词: New; Synthetic; Methodology; Natural; Product

With this award, the Synthetic Organic Program is supporting the research of Dr. Peter A. Jacobi of the Department of Chemistry at Wesleyan University. The focus of this research is the development of synthetic methodology involving the electrocyclic chemistry of cross-conjugated enynones and the use of homochiral acetylenic acid derivatives as natural products precursors. Professor Jacobi will focus his work on the synthesis of natural products possesing interesting biological properties. Targets for preparation include a number of antibiotics, antifungals and prostanoids.

凭借该奖项，合成有机项目将支持卫斯理大学化学系 Peter A. Jacobi 博士的研究。这项研究的重点是开发涉及交叉共轭烯酮的电循环化学的合成方法以及使用纯手性乙炔酸衍生物作为天然产物前体。 Jacobi教授的工作重点是合成具有有趣生物特性的天然产物。制备的靶标包括多种抗生素、抗真菌药和前列腺素类药物。