The Role of Age-Related Changes to Cortical and Trabecular Bone in the Occurrence of Traumatic and Atraumatic Vertebral Fractures (Engineering)

皮质骨和骨小梁与年龄相关的变化在创伤性和非创伤性椎骨骨折发生中的作用（工程）

• 批准号: 9450148
• 负责人: Michele Grimm
• 金额: $ 17.97万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9450148&HistoricalAwards=false
• 关键词: Role; Age; Related; Changes; Cortical

Two modalities of injury can result in wedge fractures of the vertebrae: atraumatic, osteoporotic fracture and seat-belt induced fracture during vehicular frontal impact. To reduce occurrence of these fractures, enhanced knowledge of the fracture mechanisms and determinants of vertebral strength is required. The objective of this research is to improve the current understanding of these areas of biomechanics. Ultrasound technology will be used to determine material properties for developing finite element models of spinal functional units, and the contributions of cortical and trabecular bone to vertebral strength will be assessed. Whole body and regional impact experiments will be conducted to determine the correlation between fracture mechanics and mechanical properties. Computational and experimental results will be compared for validation. Interactive activities will include teaching a combined undergraduate/graduate course in biomaterials during each of the first two years and an advanced course in biomaterials the third year. Additionally, seminars will be organized featuring experts in bioengineering. About 50 percent of the speakers will be women researchers. Workshops will be organized and opportunities for male and female students to visit research laboratories of women in industry, hospitals, and other universities will be offered through the Society of Women Engineers and ASME.

两种损伤模式可导致椎骨楔形骨折：非创伤性骨折、椎体骨折和车辆正面碰撞时安全带引起的骨折。 为了减少这些骨折的发生，需要加强对骨折机制和椎体强度决定因素的认识。 这项研究的目的是提高目前对这些生物力学领域的理解。 超声技术将用于确定材料特性，以开发脊柱功能单元的有限元模型，并评估皮质骨和松质骨对椎体强度的贡献。 将进行整体和区域冲击实验，以确定断裂力学和机械性能之间的相关性。 计算和实验结果将进行比较验证。 互动活动将包括在头两年的每一年教授生物材料的本科生/研究生课程，并在第三年教授生物材料的高级课程。 此外，还将组织由生物工程专家参加的研讨会。 大约50%的演讲者将是女性研究人员。 将举办讲习班，并通过女工程师协会和美国机械工程师协会，为男女学生提供参观工业、医院和其他大学的妇女研究实验室的机会。