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Development of Small Macrocyclic Antibody-Like Scaffolds (SMALS) for therapeutic inhibition of Nodal

Development of Small Macrocyclic Antibody-Like Scaffolds (SMALS) for therapeutic inhibition of Nodal
开发用于治疗性抑制 Nodal 的小大环抗体样支架 (SMALS)
批准号:
408349
负责人:
Derda Ratmir
金额:
$61.3万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-09-01 至 2024-09-01

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中文摘要
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英文摘要
NODAL is a protein that is normally in stem cells but that re-emerges in cancer, where it promotes cancer progression and metastasis. We have recently shown that NODAL may drive chemoresistance in ovarian cancer. Accordingly, inhibiting NODAL seems to imp
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Probing the Role of Glycans in Immunooncology using Genetically Encoded "Liquid Glycan Arrays"
  • 批准号:
    453419
  • 项目类别:
    Operating Grants
  • 资助金额:
    $68.83万
  • 财政年份:
    2021
  • 负责人:
    Derda Ratmir
  • 依托单位:
Chemical genetic screen for cell surface receptors that control cancer stem cell differentiation
  • 批准号:
    313957
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2014
  • 负责人:
    Derda Ratmir
  • 依托单位:
海外基金