Dienophilicity of Indole and Pyrrole in Inverse Electron Demand Diels-Alder Reactions; Exploration and Synthetic Applications

逆电子需求狄尔斯-阿尔德反应中吲哚和吡咯的双烯性；

• 批准号: 9501069
• 负责人: John Snyder
• 金额: $ 23.67万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9501069&HistoricalAwards=false
• 关键词: Dienophilicity; Indole; Pyrrole; Inverse; Electron

The focus of this research is the development of synthetic methodology using inverse electron demand Diels-Alder cycloadditions utilizing indole and pyrrole as dienophiles. Targets of the methodology include Aspidosperma alkaloids, beta-carbolines, carbazole alkaloids and azaindole analogues of indole alkaloids. With this award, the Synthetic Organic Program is supporting the research of Dr. John K. Snyder of the Department of Chemistry at Boston University. Professor Snyder will focus his work on the use of cycloaddition methodology for the synthesis of alkaloid natural products that have interesting biological properties

本研究的重点是利用吲哚和吡咯作为亲二酚，利用逆电子需求diols - alder环加成的合成方法的发展。该方法的目标包括蛇皮菌生物碱、-碳碱、咔唑生物碱和吲哚生物碱的辛哚类似物。有了这个奖项，合成有机项目支持了波士顿大学化学系的约翰·k·斯奈德博士的研究。施耐德教授将把他的工作重点放在使用环加成方法合成具有有趣生物学特性的生物碱天然产物上