CAREER: Nuclelar Magnetic Resonance Analysis of Protein Conformation During Bioprocessing

9501909费尔南德斯这个项目是研究利用详细的残留水平的结构信息，可从核磁共振（NMR），以检查蛋白质在非天然环境相关的制造。 蛋白质将在各种环境中进行检查，目的是对沉淀过程中的蛋白质变性有一个总体的了解。 将采用NMR检查聚集/沉淀前溶液状态下发生的构象变化、相变时发生的构象变化以及这些变化的速率。 除了这项研究活动外，研究员还将通过参与课程开发、实验室开发和指导活动来加强教育。 ****

9501909 Fernandez This project is on research to exploit the detailed residue-level structural information available from nuclear magnetic resonance (NMR) to examine proteins in non-native environments relevant to manufacturing. Proteins will be examined in a variety of environments with the goal of developing a general understanding of protein denaturation during precipitation. Changes in conformation that occur in the solution state before aggregation/precipitation, conformation changes that occur upon phase change, and the rates of these changes will be examined with NMR. In addition to this research activity, the investigator will enhance education by engaging in activities on curricular development, laboratory development and mentoring. ****