To investigate the functional role of NCAM1 in pediatric acute megakaryoblastic leukemia (AMKL) associated with the CBFA2T3-GLIS2 gene fusion

探讨 NCAM1 在与 CBFA2T3-GLIS2 基因融合相关的儿童急性巨核细胞白血病 (AMKL) 中的功能作用

• 批准号: 449324
• 负责人: Cheetham Emma R
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449324&lang=en
• 关键词: Acute Megakaryoblastic Leukemia; Cbfa2t3-Glis2 Fusion; Cell Lines; Dose Response Analyses; Functional Assays; Gene Expression; Human Cord Blood; Knockdown; Neural Cell Adhesion Molecule 1; Xenograft Models

Acute megakaryoblastic leukemia (AMKL), a subtype of acute myeloid leukemia (AML), is a pediatric disease affecting infants and children less than 3 years old. This rare subtype of leukemia is commonly associated with genetic mutations and fusions that wo

急性巨核母细胞白血病（AMKL）是急性髓性白血病（AML）的一种亚型，是一种影响婴儿和3岁以下儿童的儿科疾病。这种罕见的白血病亚型通常与基因突变和融合有关