U.S.-Italy Symposium: Glucose-6-phosphate Dehydrogenase Deficiency, Diet, and Adaptation to Malaria

美国-意大利研讨会：6-磷酸葡萄糖脱氢酶缺乏、饮食和对疟疾的适应

• 批准号: 9506133
• 负责人: Lawrence Greene
• 金额: $ 0.69万
• 依托单位: University of Massachusetts Boston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9506133&HistoricalAwards=false
• 关键词: U.S.; Italy; Symposium; Glucose; phosphate

This award supports a joint U.S.-Italian symposium, `Glucose-6-phosphate Dehydrogenase Deficiency, Diet, and Adaptation to Malaria,` to be held in Cortona, Italy, July 3 - 5, 1995, under the auspices of the Congress of the International Union of Anthropological and Ethnological Sciences. The organizers of the symposium are Lawrence S. Greene of the University of Massachusetts, Boston, and Maria Danubio, University of L'Aquila, in Italy. The proposal will fund the attendance of six U.S. investigators at the symposium. The symposium will focus on : molecular variability at the G6PD locus; the biochemistry of favism; antimalarial action of the favic compounds and other oxidant substances of plant origin; the interaction of G6PD deficiency and dietary oxidants in providing antimalarial protection; distribution of alleles for G6PD deficiency in Sardinia and its relationship to altitude and past malarial history. The Italian side will be represented by 15 Italian investigators and several other international scholars. The Italians are world leaders in the study of G6PD deficiency in adaptation to falciparum malaria. The Americans will contribute their unique perspective on how biocultural adaptation has operated at the G6PD locus.

该奖项支持联合美国-意大利专题讨论会，“葡萄糖-6-磷酸脱氢酶缺乏症、饮食和适应疟疾”，拟于1995年7月3日至5日在意大利科尔托纳举行，由国际人类学和人种学联合会大会主持。 研讨会的组织者是劳伦斯S。波士顿马萨诸塞州大学的格林和意大利拉奎拉大学的玛丽亚·达努比奥。 该提案将资助六名美国调查人员参加研讨会。 专题讨论会将集中于：在G6 PD基因座的分子变异性; favism的生物化学; favic化合物和植物来源的其他氧化物质的抗疟作用; G6 PD缺乏症和饮食氧化剂在提供抗疟保护方面的相互作用;撒丁岛G6 PD缺乏症等位基因的分布及其与海拔高度和过去疟疾史的关系。 意大利方面将由15名意大利调查人员和其他几名国际学者代表。 意大利人在研究G6 PD缺乏症对恶性疟疾的适应方面处于世界领先地位。 美国人将贡献他们对生物文化适应如何在G6 PD位点运作的独特观点。