HIV-1 glycoprotein gp41's roles in both immune misdirection and suppression

HIV-1糖蛋白gp41在免疫误导和抑制中的作用

• 批准号: 441154
• 负责人: Vance Tyler D
• 金额: $ 6.56万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441154&lang=en
• 关键词: Antigen-Antibody Interaction; Biophysical Assays; Discovery Of Immune Evasion Mechanisms; Hiv Glycoproteins; Immune Modulations (Suppression V. Dominance); Molecular Dynamics Simulations; Nuclear Magnetic Resonance; Vaccine Design; Viral Fusion; X-Ray Cry

Viruses need access to the inside of a host's cells in order to proliferate and launch an effective infection. They have therefore developed protein molecules to fuse with the outside of human cells and subsequently transfer themselves (or at least the po

病毒需要进入宿主细胞内部，以便增殖和发动有效的感染。因此，他们开发出了与人体细胞外部融合的蛋白质分子，并随后将自身（或至少是蛋白质分子）转移到人体细胞中。