Design of Glycolytic Capacities in Muscles: Do Honeybees Have Enough or Too Much Enzyme?

肌肉糖酵解能力的设计：蜜蜂是否有足够或太多的酶？

• 批准号: 9507407
• 负责人: Raul Suarez
• 金额: --
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9507407&HistoricalAwards=false
• 关键词: Design; Glycolytic; Capacities; Muscles; Do

9507407 Suarez It is important, if one is to understand the nature of physiological and biochemical processes, the manner in which they are regulated, how they might go wrong under pathological conditions, to have a fundamental understanding of the rules that govern functional design. At the level of the whole animal, the understanding of why humans and various species of animals might have so much lung, or heart, or intestine, and how the functional capacities of these organs relate to maximum physiological requirements is increasing. This approach to the analysis of design has not been adopted in studies of the design of metabolic pathways. By examining maximum rates of metabolism in muscles and by comparing these maximum rates with the capacities of the biochemical systems that make them possible, Dr. Suarez hopes to gain valuable insights into how metabolism actually works and is regulated in exercising muscles as well as into the rules of nature regarding the relationships between biochemical design and physiological performance. ***

9507407苏亚雷斯如果要了解生理和生化过程的性质，了解它们被监管的方式，在病理条件下它们可能如何出错，对管理功能设计的规则有一个基本的了解是很重要的。在整个动物的层面上，对为什么人类和各种动物可能有如此多的肺、心脏或肠道，以及这些器官的功能能力如何与最大生理需求相关的理解正在增加。这种分析设计的方法在代谢途径设计的研究中尚未被采用。通过检测肌肉的最大新陈代谢速率，并将这些最大新陈代谢速率与使其成为可能的生化系统的能力进行比较，苏亚雷斯博士希望获得有价值的见解，以了解新陈代谢在锻炼肌肉时实际上是如何运作和调节的，以及关于生化设计与生理表现之间的关系的自然规律。***