RPG: Molecular & Cellular Interphyletic Homology of Segmentation

角色扮演游戏：分子

• 批准号: 9509099
• 负责人: Cathy Wedeen
• 金额: $ 1.8万
• 依托单位: New York Medical College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9509099&HistoricalAwards=false
• 关键词: RPG; Molecular; & Cellular; Interphyletic

9509099 Wedeen the investigator will determine whether homologs of genes that control development in an animal like the fruit fly, that generates all of its segments simultaneously, can control development in an animal like the leech, that adds segments progressively. She will examine the expression patterns of genes that are likely to be involved in organizing body pattern in the leech embryo, Helobdella triserialis. The genes to be examined are homologs of the genes engrailed, cubitus interruptus-Dominant, wingless and hedgehog that are expressed in stripco in the embryo of the fruit fly, Drosophila melanogaster, and have been shown in that insect to be required for normal development of embryonic segments. The cells in the leech embryo expressing these genes will be identified by their cell lineage and will be ablated by laser to examine what role these cells play in embryonic development.

小行星9509099 研究人员将确定控制果蝇等动物发育的基因的同源物是否可以控制水蛭等动物的发育，这些基因同时产生所有片段。 她将研究基因的表达模式，这些基因可能与水蛭胚胎Helobdella tisserialis的身体结构有关。 待检测的基因是在果蝇（Drosophila melanogaster）胚胎中以条带形式表达的engliled、cubitus interruptus-Dominant、wingless和hedgehog基因的同源物，并且已显示在该昆虫中是胚胎节正常发育所需的。 水蛭胚胎中表达这些基因的细胞将通过它们的细胞谱系来识别，并将通过激光消融来检查这些细胞在胚胎发育中起什么作用。